Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Centre for Africa Studies concludes ANC Centenary Dialogue series
2013-02-20

 

Attending the closing seminar were from left: Prof Chris Saunders, Editor of the ANC Centenary dialogue book; Vincent Khetha from the Free State Provincial Government’s Department of Sport, Arts, Culture and Recreation; Prof Kwesi Prah; Siphamandla Zondi, Editor of the ANC Centenary dialogue book; Dr Dennis Goldberg and Prof Kwandiwe Kondlo.
Photo: Steffi Cawood
20 February 2013

Speech:"The future of South Africa in Africa" (pdf)

The Centre for Africa Studies received praise for the series of dialogues it hosted on the ruling ANC party, conversations which started before the party held its 53rd National Conference on our Bloemfontein Campus.

The Centre recently hosted the last seminar in the ANC Centenary Dialogue series, a project which started in November 2010 when the ruling party prepared for its centenary celebrations in 2012.

Prof Kwandiwe Kondlo, former Head of the Centre, and currently professor at the University of Johannesburg, told guests at the closing seminar, "it was a job well done which kept dialogue going on". Prof Kondlo said a book with a collection of papers presented during the series is being finalised, with senior ANC officials expected to attend the book launch on the Bloemfontein Campus later this year. The book features chapters by scholars like Profs Stephen Ellis, Shireen Hassim, Colin Bundy and Ben Turok and covers topics on the role of women in the liberation struggle, the party's economic policy and the history of the party in exile.

Speakers at the closing seminar included Prof Kwesi Prah, whom Prof Kondlo introduced as "one of Afica's intellectual giants,” struggle veteran, Dr Dennis Goldberg and the new Head of the Centre for Africa Studies, Prof Heidi Hudson.

Prof Prah, who delivered the keynote address, spoke about "The future of South Africa in Africa."

 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept