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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Learners to benefit from UFS Partnership for academic excellence
2013-02-21

 

Thokoana Makaota learners listening attentively during the launch of the partnership with the UFS.
Photo: Thabo Kessah
21 February 2013

The university’s quest for academic excellence in the education system paved the way for the Faculty of Education on the Qwaqwa Campus to enter into a mutually beneficial partnership with a local school, Thokoana Makaota Secondary.

This recently launched partnership will enable learners who are currently in grades 10-12 to attend supplementary classes on the campus.

“The aim of this partnership is to expose learners from the school to adequate tuition in subjects that are generally perceived as difficult. We want them to gain as much confidence as possible when tackling these subjects, therefore they will be using our well-equipped laboratories and classes”, said Dr Lekhooe Letsie, the Programme Coordinator.

“We will also benefit from this as our own final-year education students will act as tutors. This will help them gain confidence before they venture into the real job market next year,” Dr Letsie said.

Dr Letsie also revealed that the student-teachers will be closely monitored by their mentors to ensure maximum success.

The school’s Deputy Principal and UFS alumnus, Serame Sello, said that the school felt humbled by this gesture from the UFS.

“We are confident that this working relationship will yield very positive results for the school and enable us to improve on the 84% pass rate obtained in 2012,” Sello said.

“We did not do so well in the subjects that will be covered here. For instance, we obtained 43% and 61% in Physical Science and Mathematics respectively, but with this partnership we hope for improved results this year,” said Sello.

Other subjects to be covered include Geography, Life Sciences, Economics, and Accounting. The different grades will commute to and from campus on different afternoons.

 

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