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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

School of Medicine boasts with a new unit
2013-02-22

 

New Clinical Skills Simulation unit is one of its kind.
Photo: Supplied
22 February 2013


The Faculty of Health Sciences at the University of the Free State (UFS) can now boasts with a new Medical Clinical Skills Simulation unit (MCSU) at the School of Medicine.

This newly established Clinical Simulation Unit is the first dedicated clinical simulation unit of its kind in South Africa. It was opened on Thursday 21 February 2013.

This facility is equipped with an operating theatre, Intensive Care Unit, two simulation and three private rooms.

In addition, the Unit has control rooms with cameras for recording purposes and debriefing facilities, the latter with video equipment for playback of recorded scenarios.

The Simulation Unit at the UFS’ School of Medicine is based on accredited units in the USA and the UK.

Dr Mathys Labuschagne, Head of the Simulation Unit, says the concept for this kind of unit is still new, but is already a very important part of clinical skills training in the health professions.

“We are the only university in South Africa with a unit dedicated to clinical skills simulation only and not a combination of clinical skills training which includes some simulation.”

The primary goal of the MCSU is to provide educational opportunities to undergraduate and postgraduate medical students, as well as opportunities for other healthcare students in the Faculty of Health Sciences, to be exposed to inter-professional skills training. The MCSU will play a role in quality assurance of training and assessment, as well as research.

The aim of the Clinical Simulation Unit is to provide a facility where medical and other healthcare students or professionals can be exposed to:

  • Training in a safe environment.
  • Training without harm to the patient.
  • Scenario-based learning.
  • Debriefing.

The facility will also be utilised for post-qualification refresher and training courses.

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