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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Prof Hussein Solomon, an expert voice on Islam in Africa
2013-02-25

Prof Hussein Solomon
Photo: Supplied
25 February 2013

Prof Hussein Solomon, Senior Professor in the Department Political Studies and Governance, has been appointed Senior Research Associate of the Israeli think tank Research on Islam and Muslims in Africa (RIMA). 

Prof Solomon will give an expert voice on the topic of Islam in Africa, participating with other researchers in the network on political Islam and terrorism on the African continent. The centre is the only one in the world which solely deals with Islam and Muslims in Africa.

An expert on the topic of Islam on the continent, Prof Solomon says it’s an important focus area given the rise of Al Shabab in Somalia and its terrorist attacks across the world. He further mentions the rise of Al Qaeda in the Islamic Maghreb and other such groups operating in Northern Mali, prompting the recent French intervention, as well as the increasing incidence of terrorism in Nigeria perpetrated by the Islamist Boko Haram.  "If you want to save lives, then you need to understand how such movements originated and how they operate."

The academic says through RIMA and its global network, he will work with other researchers and engage in collaborative research projects on the same issue, allowing for the rapid cross-pollination of ideas. "For the University of the Free State, it once more underscores the fact that, with the information age, you do not have to be in the capital of the country to be globally relevant. Indeed, in recent years the University of the Free State has increasingly been seen as a global actor in the academic arena."

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