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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Breyten Breytenbach shares his words and philosophies

2013-03-05

Breyten Breytenbach
Photo: Johan Roux
02 March 2013

The Department of Philosophy at the University of the Free State (UFS) recently hosted Breyten Breytenbach as part of its Colloquium series.

In a packed Odeion theatre, Breytenbach shared his words and views relating to poetry and philosophy. The session was chaired by Prof Pieter Duvenhage from the Department of Philosophy, who noted the symbiotic relationship which exists between the two seemingly distinct disciplines.

Breytenbach is one of South Africa’s best-known literary sons, gaining worldwide recognition for his writings and poetry, as well as his political activism against the erstwhile Apartheid regime. He left the country in 1960 due to Apartheid and settled in Paris where his first collection of poetry was published in 1964. It was the beginning of a prizewinning literary career spanning multiple languages and decades.

He returned illegally in 1975 in order to agitate against the repressive National Party government, but was arrested, spending seven years in prison after being charged with terrorism.

The audience was treated to a reading from an unpublished work from Breytenbach, A letter to my daughter. The lengthy letter outlined Breytenbach's world views, his sense of the creative process, his philosophies and his takes on current and historical events.

A large part of the letter focused on the philosophical and emotional processes involved in writing.“Writing is the travelling of its own landscape; landscapes and rooms that may always have been there,” he said.

He noted that it’s not always an easy process, and that sometimes writers need to explore the abysses, which can be unnerving.

“In this regard it is important to know that emptiness exists,” he said.

He stressed his concern over some of the problems the country currently faces, especially the abuse of state institutions. He was especially worried about the abuse of power. He warned that “power has its own predatory identity,” often abused and misused by those who wield it.

Despite his misgivings, Breytenbach still retains his optimism for the country and its people. He remarked that the country and its many diverse cultures resembles a “fantastic patchwork blanket,” one that should be cherished and protected.

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