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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New residences officially open
2013-03-06

 
Celebrating the official opening of the two new residences, were Vusumzi Mesatywa, Prime of House Outeniqua and Sherilyn Roelofse, Prime of House ConLaurês.
Photo: Johan Roux
06 March 2013

 

  Video clip (YouTube)

The one implies dreams of victory; the name of the other means ‘bringers of honey’ in the Khoisan language.

With these unique names, two new residences, House ConLaurês and House Outeniqua, will create new memories for generations of Kovsie students. The two residences were officially opened on the Bloemfontein Campus of the University of the Free State, bringing the number of junior residences on the campus to 19.

Celebrating the new addition to residence life, Mr Quintin Koetaan, Director: Housing and Residence Affairs, told residents of House ConLaurês and House Outeniqua that they were part of history. He told guests that the residences will provide accommodation for a new generation of students and encouraged residents to breathe life into their respective abodes.

“Nobody thought that two residences could be built in a year,” he said about the short time between the planning and opening of the residences in January this year. The two residences welcomed 250 students each, with male and female students living under one roof, but in separate units.

Prof Jonathan Jansen, Vice-Chancellor and Rector, praised Koetaan and his team, as well as the developers, saying they have done something completely different on the campus. He said the two residences will create a place which students can call home. “It will create a place not just to eat and sleep, but also to learn. It will create memories for many years to come.”

Mr Rudi Buys, Dean: Student Affairs, said House ConLaurês and House Outeniqua is much more than simply residences. “It’s about the university putting its heart out there, showing what can be done.” He told guests that representatives from other universities and the Department of Higher Education and Training have visited the UFS to see what is being done here.

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