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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Public Protector visited Faculty of Law
2005-09-23

On 21 September 2005 the Public Protector visited the Faculty of Law.  This event took place at 10:00 in the Senate Hall of the CR Swart Building, after which a light lunch was served for the delegates and staff of the Faculty.

The purpose of the visit was to spell out the roles, functions and powers of the Public Protector, to promote public awareness and transparency and to increase contact between the Faculty and the Public Protector.  Sufficient time was allowed to answer all the questions posed by various parties, and brochures were made available.

All law students and staff members of the Faculty were invited to the occasion.  The presentations also included information regarding career possibilities for students with the Public Protector’s office.  This organization is more than willing to involve students in community service projects and would keep in contact with the Faculty in this regard.

All the representatives of the Public Protector’s office who visited the Faculty are in the law profession:

The following persons made presentations:

Mr P Nthotso:  Independent Complaints Directorate
Ms L Mdalane: Directorate of Special Operations – Scorpions
Ms M Thetlhu: South African Human Rights Commission
Mr A Madiba:  Office of the Public Protector.

The persons mentioned above were accompanied by their supervisors, viz. Mr L Mashee (Head Public Awareness, Free State) and Ms SD Griessel (Provincial representative for the Public Protector, Free State).  A further two employees of the Public Protector attended as observers, viz. Mr T Kgabeginyane and Mr MR Matlesoane.

The Public Protector functions independently and reports directly to Parliament.

Staff and students found the visit very informative and valuable contacts were made in the process.

 



Back from left:
Ms Michelle Havenga (President of the Faculty of Law's Juridical Society ), Ms Masego Thethu (South African Human Rights Commission), Ms  Lebo Mdalane (Directorate Special Projects of the Scorpions) and Mr  Pieter Nthotso (Independent Complaints Directorate).
Front from left: Mrs Soné Griessel (Provincial Representative of the Public Protector in the Free State) and Prof Carel van der M Fick (Head:  Department of Criminal Procedure and Philosophy of Law at the UFS Faculty of Law).

 

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