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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Two academics will be sorely missed

2013-04-02

Prof Andrew Marston and Prof Bannie Britz
Photo: Supplied
02 April 2013

The staff and students of the University of the Free State (UFS) are deeply saddened by the recent passing in Bloemfontein of two of the university’s most esteemed and renowned academics, Prof Bannie Britz and Prof Andrew Marston.

Prof Britz was the Head of the Department of Architecture from 1992 to 2000. He was renowned in his field, winning numerous prizes for Architecture, including the Gold Medal for Architecture from the South African Academy of Arts and Sciences.

“As professional architect and urban designer, Prof Britz was a much awarded architect who received numerous award of merit from the South African Institute of Architects for buildings erected in South Africa over the years,” said Martie Bitzer, Head of the Department of Architecture.

Apart from his acclaim elsewhere, Prof Britz also played a major role in the day-to-day activities of university’s staff and students. He was responsible for the design of the many walkways on campus and the refurbishment of the Main Building on the Bloemfontein Campus. For the many contributions in his field, Prof Britz was awarded an Honorary Doctorate by the UFS in 2007.

Prof Andrew Marston, a specialist in natural product chemistry and methods associated with the isolation and analysis of medically important chemicals from plants, was appointed from Geneva, Switzerland in 2009 under the UFS Strategic Cluster for Advanced Biomolecular Research.

He obtained a B-rating from the National Research Foundation (NRF) in 2011, and was consequently appointed as a senior professor in die UFS Senior Professor Programme. “He has made valuable contributions to the UFS in terms of teaching and postgraduate supervision, as well as research. In his short stay at the UFS, he already co-authored more than ten papers in international chemistry literature,” said Prof André Roodt, Head of the Department of Chemistry.

His research group was part of a multilateral agreement in the European Union (EU) with a number of African and three European universities. He obtained new research funding from the Seventh Framework Programme of the EU for the Building Sustainable Research Capacity on Plants for Better Public Health in Africa project, from the Norwegian Research Council for bioprospecting and the isolation and structure determination of compounds from plants and algae, and from the South African Rooibos Tea Council.

The memorial service for Prof Britz took place on Friday 5 April 2013 in the Berg-en-Dal Dutch Reformed Church in Bloemfontein. The service for Prof Marston took place in the Trinity Church, Charles Street, Bloemfontein.

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