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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Students excel at National Championships for the Physically Disabled

2013-04-07

South African record-holder Danie Breitenbach (left) running with his guide at the 2013 Nedbank National Championships for the Physically Disabled.
Photo: Hetsie Veitch
10 April 2013

Six gold, one silver and two bronze medals. That is the number of medals students of the University of the Free State won at the 2013 Nedbank National Championships for the Physically Disabled, held in Pretoria.

Louzanne Coetzee, Danie Breitenbach, Juanré Jenkinson and Diederich Kleynhans held the Kovsie flag high, winning medals in track and field events. Louzanne and Danie, both visually-impaired students, each won three gold medals, with Danie setting two new South African track records. Danie, who took part in the T11/F11 sports class for visually-impaired, totally blind athletes, set records in the 800 and 1 500 metre track events. This first-year BA student, who runs with a guide and has to wear a blindfold when running, also won a gold medal in the 400-metre track event.

Louzanne also took part in the T11/F11 sports class and won gold medals in the 800-, 1 500- and 5 000-metre events. With her winning time of 2 minutes and 53,8 seconds in the 800 metres, Louzanne, a second-year BA Corporate and Marketing Communication student, reached the qualifying standard for international participation. She may be considered for a national team that will compete internationally.

Diederich and Juanré took part in the F37 and F38 sports class for physically-impaired athletes and won medals in the field events. Juanré, a fourth-year Education student, and Diederich, a master’s degree Theology student, won bronze and silver medals in shotput. Diederich also won a bronze medal in discus.

Also taking part in the national championships, were Sidwell Monyane, a final-year B Public Management (Human Resource Management) student. Sidwell was part of the Free State Boccia team. Boccia is a target-ball sport for athletes with disabilities, which has a major impact on motor skills.

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