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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Autumn Graduation Ceremony a thrilling showcase
2013-04-19

 

Yolanda du Toit from the Department Student Academic Services is the proud mother of three daughters who all received qualifications at the Autumn Graduation. Maryke (left) received her certificate in Certified Financial Planning. She already has degrees in B.Com. Law and LLB. Amandi (centre) received her B.Ed and twin sister received her degree in consumer science.
Photo: Renè-Jean van der Berg
19 April 2013

Gareth Cliff video clip
Vicus and Vincent Visser video clip
Joshua Johnson video clip
Graduation YouTube video clip

Photo Gallery

The university’s Autumn Graduation Ceremony infused the Bloemfontein Campus with exhilaration last week.

Beaming with pride, graduates received 526 diplomas/certificates and 2 796 bachelor’s and honours degrees in total.

Prof Jonathan Jansen, Vice-Chancellor and Rector, lead each procession of graduates from the Red Square down the path to the Callie Human Centre while the beat of drums filled the air. “To break the cycle of poverty, get an education, get a degree,” Prof Jansen urged graduates during their respective ceremonies. He underscored the fact that, as graduates, they are ten times more likely to get a job, with the odds rising as they continue their postgraduate studies.

Dr Khotso Mohele, Chancellor of the university, advised graduates not to allow life’s obstacles to discourage them. “Take what you have learned over the last three or four years and use that knowledge to reach your goal,” he said. He also emphasised that graduates need to be able to take standpoint against issues.

Graduates’ ceremonies were made even more memorable by various local and international speakers and performers.

American student and tap-dancer, Joshua Johnson, inspired the audience with his story of hope and perseverance. As a student from Penn State University, he travels five hours by bus to New York every weekend where he dances on the subway train to earn money for his tuition fees. Joshua told graduates that, in order to achieve their goals, they have to make the best use of the 24 hours they get to live daily. “Don’t follow in the footsteps of someone else. Take the beat of life, but add your rhythm to it," his wise words resonated with the exhilarated graduates. The audience could not help but clap to the rhythmic beat of his tap-dancing performance.

Vicus Visser, dubbed Bloemfontein’s Justin Bieber was also on the list of performers. Vicus – a South African YouTube singing sensation – performed with his brother, Vincent, to the delight of the crowd.

Radio personality and Idols South Africa judge, Gareth Cliff, was also among the speakers who addressed the graduates during the week. “It’s a good time be alive, a good time to be a South African, a good time to be a qualified South African,” he said. “It’s a time in our country’s development that we require minds such as yours to propel us forward,” was part of his message. Gareth also stressed the freedom of speech in South Africa, especially the freedom of the media.

The Autumn Graduation Ceremony of 2013 was an immense success and filled the hearts of Kovsie graduates, students, staff, parents, family and friends with overwhelming pride.

The Qwaqwa Campus’ graduation ceremony will take place on 8 June 2013. Diplomas / certificates up to and including doctorates will be awarded at this ceremony.

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