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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Qwaqwa Campus launches No Student Hungry Programme
2013-05-02

 

Samkelo Duma (white shirt) flanked by some of the guests during the launch of the NSH Programme on the Qwaqwa Campus.
Photo: Thabo Kessah
02 May 2013

The Qwaqwa Campus of the University of the Free State launched the No Student Hungry (NSH) Programme on Friday 26 April 2013. The programme aims to provide needy students with a daily balanced meal to enable them to concentrate in class and ultimately obtain their degrees. The programme – initiated by Vice-Chancellor and Rector Prof Jonathan Jansen in 2011 on the Bloemfontein Campus – already feeds hundreds of students.

Rudi Buys, Dean of Student Affairs who represented the Rectorate, encouraged students in need to focus more on their desire for greatness.

“Through this programme, you will be able you to shift your focus from the hunger pangs and rather focus all your energy on the hunger to make Africa great,” said Buys. “We want you to be different from the rest of your generation that is reluctant to compete for greatness. Many of your peers prefer mediocrity and it is our wish that through this programme, you can start learning to compete with the best,” Buys impelled.

According to the Qwaqwa Campus programme co-coordinator, Selloane Phoofolo, NSH operates on a primary and a secondary level.

“The primary level offers a food bursary to the students whose academic performance is above 65 percent and not receiving any form of financial assistance. For the 2013 academic year, we had 53 students applying and 31 have qualified. They are getting a meal for R25.00 a day at the Dining Hall,” said Phoofolo.

She further explained that, “On the secondary level, we provide monthly food parcels to 19 students who did not qualify for the food bursary. These food parcels are donated by Pick n Pay and Stop Hunger Now SA. For this, beneficiaries must undertake 40 hours of community service during the year. They must also partake in student activities. Their academic progress is monitored by the Office of Social Work.”

One of the beneficiaries, a final-year BA degree student Samkelo Duma, expressed his gratitude towards the UFS for giving him an equal opportunity to those in more fortunate situations to do his best in his studies. “It is difficult to study and concentrate on an empty stomach and I must say that the NSH is very helpful. I do not just get a meal, but I get a healthy meal to keep me going throughout the tough day,” Duma said.

Also present at the launch were the patrons of the programme, Ms Grace Jansen and Dr Carin Buys. They volunteer their time and energy to raise funds for the project.

Students apply for the allowances and are selected on the basis of financial need, academic results, active participation in student life programmes and commitment to give something back to the community.

You can also invest in these students' future by contributing R10.00 each time you sms the word 'Answer' to 38722.

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