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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Postgraduates’ new Kovsies home
2013-05-10

 
Some of the guests attending the launch, included from left: Prof Driekie Hay, Vice-Rector: Academic, Dr Henriette van den Berg, Director: Postgraduate School and Prof Corli Witthuhn, Vice-Rector: Research.
10 May 2013
Photo: Johan Roux

Postgraduate students and their academic 'parents' at the University of the Free State (UFS) now have a dedicated physical, emotional and electronic space to provide for their specialised needs in order to further promote research excellence at the UFS.

The university's Postgraduate School was launched in May 2011, but ventured further in the quest to fulfil and expand its mandate with new initiatives. These different aspects of the school were launched on Wednesday 8 May 2013 in the CR Swart Auditorium on the Bloemfontein Campus. The postgraduate strategy, postgraduate prospectus, the website and the headquarters of the Postgraduate School in the Johannes Brill Building were all unveiled and launched.

Prof Driekie Hay, Vice-Rector: Academic, who was a major driving force behind the formation of the Postgraduate School, during her address at the opening emphasised the multifaceted and unique relationships which often exist between students and supervisors.

Prof Hay, who has a distinguished academic background in postgraduate teaching, made plain her expectations for the Postgraduate School. She said it aims to "create an intellectual space for postgraduate students and supervisors" in order to produce world-class intellectuals at this university.

She said the school will empower both students who often don't know what to expect from supervision, as well as supervisors who often lack supervision skills. Through this it will be possible to create healthy, productive relationships between the distinct pairs in often misunderstood, unbalanced and intricate interactions.

Dr Henriette van den Berg, Director of the Postgraduate School, introduced the strategic plan of the school and emphasised the great strides that have already been made and what still needs to be done at the UFS in terms of postgraduate teaching. According to her, the Postgraduate School aims towards "holistic development of postgraduate students with transferable skills," through a multi-level and institution-wide approach at the university.

"Our aim is to develop a one-step service for postgraduate students, involving all the different stakeholders," she said.

The new Postgraduate School website was also showcased during the event. Reachable through a number of avenues on the main website, the site offers a digital version of the Johannes Brill Building. Brimming with features catering specifically for local, international, current and prospective students, the website provides crucial information.

The Johannes Brill Building's refurbished interior, with staff offices, seminar rooms and social spaces, were also showcased to UFS' staff and students. The initial phase of the Supervisors' Wall of Fame was also unveiled. According to Dr van den Berg , the wall will after completion bestow much-deserved praise on a hand-picked group of 60 supervisors who have respectively been responsible for more than 300 and more than 500 successful PhD and master's candidates over the past decade.

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