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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsie students selected for prestigious study travel programme
2013-05-15

 

Golden Key International Honour Society members, Michael van Niekerk, Siobhan Canavan, Mpoi Makhetha and Cebolenkosi Sokhela, will travel to the USA and China, meeting the best in their career fields.
Photo: Hannes Pieterse
15 May 2013


They are amongst the top 15 percent of academic achievers at the university, and have been afforded the opportunity to travel abroad and meet with leading people in their fields of study.

Kovsie students Michael van Niekerk, Siobhan Canavan, Mpoi Makhetha and Cebolenkosi Sokhela, all members of the Golden Key International Honour Society, will travel to the USA and China. This trip is part of the International Scholar Laureate Program (ISLP) to learn how their career fields are practiced in another part of the world. The students are part of a select group of outstanding university students from across the world who will be given access to people, places and global perspectives in fields such as business, engineering, medicine, nursing, diplomacy and international relations.

Michael, a fourth-year MBChB student and SRC member of our Bloemfontein Campus, and Cebolenkosi, a third-year BSc Microbiology student will visit Washington, Philadelphia and New York in the USA. As part of the medicine delegation of the programme, they will visit clinics and hospitals to see how their study fields are practiced. Michael’s trip includes a visit to Johns Hopkins University in Baltimore, where he will meet representatives of the National Institute of Health, the largest source of funding for medical research in the world. He will also visit Harvard University in Massachusetts.

Mpoi, a third-year BSc Human Molecular Biology student, also forms part of the medicine delegation but will travel to China. "We will be exploring the ancient ways of healing versus the modern medical practices, exploring the medical systems of the country and meeting doctors and professors, visiting the rural areas, and of course, touring the best parts of China,” she said.

Siobhan, a third-year Media Studies and Journalism student, is part of the diplomacy and international relations delegation who will visit Beijing, Xi'an and Shanghai in China. "To me it's such an honour to be part of this programme,” she said. “It will give me the platform to not only represent who I am, but also my university and the values that the university has instilled in me. It allows me to be a part of something great that will benefit me in the end."

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