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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS works closely with employees in the post-Reitz settlement process

2013-05-20

20 May 2013

In the light of an article in IOL News on 18 and 19 May 2013 and in Sunday Independent and Sunday Tribune on 19 May 2013 in which it is alleged that the University of the Free State (UFS) has failed to honour its commitment to the five Reitz employees we are pleased to report on the ongoing process and progress made with respect to their employment.

The university remained consistently true to the settlement agreement and High Court order of 2011 and cannot apologise for complying with the law. It was therefore impossible for us to talk to our colleagues directly until last week when we had a breakthrough meeting, which was cleared by the Human Rights Commission (HRC), and matters were resolved.

The UFS continues to work closely and now directly with the five employees to ensure that their rights as employees remain the highest priority in the post-settlement process.

All but one of the conditions of the Reitz settlement (own business) has already been met; however, we are in the process of providing training and support for the establishment of an independent business led by the employees.

After some delays, and frustration on all sides, we have found the right training provider for them and are satisfied that the process remains on track. The business office (furnished) has been allocated at the South Campus in Bloemfontein.

Already in late 2012 the Chair of the HRC expressed his satisfaction with the commitments made by the university to the process. By 30 June 2013 this outstanding commitment to establish an independent company with trained employees would also have been met in full.

Beyond the settlement agreement, the UFS has also committed to providing free education and training to the children of the employees so that their next generation of families emerge as strong, independent, well-trained and productive members of society. The child of one of the colleagues is in fact finishing Grade 12 this year and we are in discussion about possible studies at the UFS. This is our pledge and commitment as a university.

This final step in the post-Reitz settlement is being led by Dr Choice Makhetha, Vice-Rector of the University of the Free State.

Issued by: Lacea Loader
Director Strategic Communication
Tel: +27 (0) 51 401 2584 / +27 (0) 83 645 2454
E-mail: news@ufs.ac.za
Fax: +27 (0) 51 444 6393
Web: www.ufs.ac.za

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