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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Student leaders' hard work rewarded
2013-05-01

Four student leaders on our Bloemfontein and Qwaqwa Campuses each received a scholarship of R15 000. Handré Hay, Estine Cronje, Tsepang Lenka and Jean Vermaas were rewarded for the positive impact they had on the student community in the past three years or more. Student Affairs' scholarship programme acknowledges the contribution of student leaders in the upliftment of the student community.

Read what the four have to say about leadership:

Handré Hay:

Handré Hay, a third-year BSc Physiotherapy student who holds several leadership positions on our Bloemfontein Campus, served for two consecutive years on the committee of Armentum residence. He was also a member of the executive council in the Students' Representative Council (SRC) and served in two SRC portfolios. "Leadership is about being able to serve. When people see that you are willing to put other people's interests above your own and that you are willing to serve unselfishly, despite a position of authority, you will get far," said Handré.

Estine Cronje:

Estine Cronje is the current prime of Marjolein residence. This was the second time the fifth-year Psychology student were re-elected to this position."Leadership is very important to me. One needs leaders in everything you do. I believe a leader should never think herself better than the rest and should work as hard as her team. She should command respect, be disciplined, an example to others, accessible and open to the opinions of other people.

Tsepang Lenka:

Tsepang Lenka is the SRC President of our Qwaqwa Campus. Tsepang, who was twice elected as prime of his residence, has already obtained his BA degree in Public and Business Management. He is currently working on his Postgraduate Certificate in Education (PGCE). "To me leadership means to serve. As a leader you don't lie to people when things are taking the wrong direction, you stand firm and tell the truth; in that way, people don't lose trust in you. The scholarship inspires me to work even harder," Tsepang said.

Jean Vermaas:

Jean Vermaas is a former SRC member who is currently studying for his LLB degree. Some of Jean's achievements include leadership positions of the Juridical Society and the Broad Students' Transformation Forum. In 2012 he was a founder member of the Student Elders' Council."Leadership is of extreme importance to me. It formed me into the person I am now. Leadership isn't always easy, but in the challenges you face you grow as a leader and as an individual."

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