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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Goodbye SIFE, hello Enactus
2013-05-01

The Kovsies Enactus team
24 May 2013
Photo: Linda Fekisi

The Students in Free Enterprise, better known as SIFE, has changed its brand name to Enactus. This global rebranding took place late last year. It forms part of an attempt to increase the organisation’s level of reach and impact. It reflects that entrepreneurial action is not something that is relevant to a single culture or nationality.

The organisation is still in essence one which assists university students to create community empowerment projects. The Kovsies Enactus team has 53 active members on the Bloemfontein Campus.

“We encourage student development through Enactus. It is a great platform for students. There is a combination of ideas, expertise and diversity from different faculties,” says the Vice-Chairperson of internal affairs, Mirriam Matsoaboli.

Enactus is currently working on three major projects: Local Economic Development (LED) and Edcon, Shifting Focus, and an environmental project. LED works with 19 established businesses which are struggling to make a profit while Edcon deals with three designers in textile and clothes making. Shifting Focus forms part of the educational division. It focuses on instilling entrepreneurial skills in high school learners. The Enactus team serves as a mentoring structure and advises them. The environmental project is in its infant stage, with. Enactus working on recycling bottles and paper, especially old study guides on campus.

“Having a branch on the QwaQwa campus has also been one of our objectives. We are still in the process of establishing one,” adds Mirriam.

The Enactus team is currently preparing for the national competitions which will take place later in Sandton on 10 and 11 July.

  • Students tell us about your association and we will profile it on our Kovsielife page. Contact Amanda Tongha at tonghaa@ufs.ac.za

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