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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS helps to renovate schools
2005-10-10

Photo gallery

About 250 hostel students of the University of the Free State's (UFS) main campus yesterday painted and renovated four schools in the black townships of Bloemfontein.  This was part of Kovsie Rag's new approach to be more directly involved with communities.

Students were transported with busses and performed tasks such as the painting of class rooms and outside walls and the cleaning and painting of gutters and window panes.  The painting was judged by a panel of judges, that included the Rector and Vice-Chancellor, Prof Frederick Fourie.  These points will contribute to the each hostel's final point in the Rag fund raising campaign for 2005/2006.

 

 

Some of the students who painted the gutters of Maboloka Primary School in Bochabelo were from the left Ms Tume Kowang (18) (first year student in B Accounting from NJ van der Merwe hostel); Ms  Gloria Mangwane (19) (third year student in B Sc Biochemy from NJ van der Merwe hostel); Ms Adri Ras (21) (second year student in Occupational Therapy from Emily Hobhouse hostel) and Ms Malandi Els (20) (third year student in B Exercise and Feeding from Emily Hobhouse hostel).

See attached media statement:

UFS Rag and Eimpa paints assist with upgrading of schools

The spirit of Ubuntu will this year be truly reflected in the University of the Free State’s (UFS) Rag community out reach programme when senior students from the 23 hostels on the Main Campus will visit four less-privileged schools in the Mangaung area on Saturday 8 October 2005 to assist these schools in the upgrading of facilities.

The same day (Saturday 8 October 2005) the UFS first year students will visit the neighbourhoods in Bloemfontein from 08:00-13:00 to raise funds on an Ubuntu donation lists for Rag 2005/2006.

The Ubuntu project was started about seven years ago and it has grown each year. In the past the project was associated with a fundraising leg and a hostel publicity leg.  This year the aim is to involve the community to demonstrate how important fundraising initiatives are to help those less-privileged. 
 
The schools that will be visited are Legae Intermediary School in Batho, Mothusi Primary School in Rocklands, and the Maboloka and Lesedi Primary Schools in Bochabelo.  The schools in the Manugaung area had until 31 August 2005 to complete a questionnaire identifying what assistance is needed.  The Rag office, with the help of professional consultants from Eimpa Paints, chose four schools and visited each one to determine material/s needed to complete the work. 

Eimpa Paints is a partner of the Ubuntu project and will be sponsoring all paint necessary to complete the work at the schools.  All other material/s needed will be supplied by the UFS Rag office.

The hostels are divided into project teams and will clean and paint gutters and window sills and paint the walls of classrooms and outside walls.  At Maboloka School for instance, a project team will also to paint a wall with colourful characters.

Media release
Issued by:  Lacea Loader
Media Representative
Tel:  (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za
7 October 2005

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