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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First-year students encouraged to attend UFS welcoming function
2006-01-12

The University of the Free State (UFS) will host a welcoming function for all new first-year students and their parents on Saturday 14 January 2006 in the Callie Human Centre on the Main Campus in Bloemfontein.

The function starts at 11:00 and will be addressed by the Rector and Vice-Chancellor of the UFS, Prof Frederick Fourie. UFS staff will also be available to provide vital information to first-year students on academic matters.

According to Mr Vernon Collett, Registrar: Academic Student Services at the UFS, Saturday’s welcoming function can assist students and parents by providing vital information on the many high quality academic learning programmes on offer at the UFS in six faculties.

“If students and parents have this information it will make the registration process, which starts next week Tuesday 17 January 2006, much smoother,” Mr Collett said.

The UFS has split the registration process into various categories of students and Mr Collett appealed to all students to adhere to the dates and times which apply to them as a one-stop service will be available so as to avoid unnecessary delays in the registration process.

The registration of first-time entering first-year students who applied before 30 November 2005 to study at the Bloemfontein Campus will take place from Tuesday 17 January 2006 at the Callie Human Centre.

Senior undergraduate students (that is, students entering their second or later year of study) may register from 23 January 2006.

Postgraduate students, first-time entering first-year students and other students who applied for admission to the main campus after 30 November 2005 must register at the Callie Human from 2 February 2006. 

Late applications will be accepted until Wednesday 25 January 2006 at the Information Centre on the Main Campus’ Thakaneng Bridge. These applications will be regarded as pending and will be processed as places become available on the programme the student has applied for,” said Mr Collett. 

Vista Campus:
The Vista Campus in Bloemfontein – which was incorporated into the UFS in January 2004 – no longer accepts applications from first-year students. Such prospective students had to apply to the UFS Main Campus. Students who had been registered on the Vista campus last year must register at the Vista Campus on the same dates as applicable on the Main Campus.

Qwaqwa Campus:
At the Qwaqwa Campus of the UFS, all first-time entering first-year students must report on Thursday 19 January 2006, after which the registration of these students will take place according to a specific programme. The official welcoming functioning for new first-years at the Qwaqwa campus of the UFS will take place on Saturday 11 February 2006 at 08:00 in the Rolihlahla Mandela Hall on the Qwaqwa Campus.

Mr Collett appealed to first-year students who have applied to study at the Qwaqwa Campus and their parents to attend this function which fulfils the same role as the one held on the Bloemfontein Main Campus.

Detailed information on the dates and times of registration for the various faculties and academic learning programmes is available on the UFS website at www.uovs.ac.za. Prospective students may also call the Main Campus in Bloemfontein on (051) 401-3000 or the Qwaqwa Campus on (058) 718-5000 for more information.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
10 January 2006

 

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