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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

First M degree in Sport Medicine commences at the UFS
2006-02-03

Some of the guests that attended the launch of the M degree in Sport Medicine were from the left Dr Derik Coetzee (senior lecturer at the UFS Department of Human Movement Science and one of the tutors of the programme); Dr Sorita Viljoen (a student from Bloemfontein); dr Stephan Pretorius (a student from Pretoria) ; Dr Louis Holtzhausen (Programme Director:  Sport Medicine at the UFS) and Prof Teuns Verschoor (Vice-Rector:  Academic Operations at the UFS).
Photo: Lacea Loader


First M degree in Sport Medicine commences at the UFS   
 

The classes of the first group of nine students registered for the M degree in Sport Medicine at the University of the Free State (UFS) commenced at the School of Medicine this week.

This is the first degree of its kind presented by the UFS.  Only two other universities in South Africa are presenting the course, namely the University of Cape Town and the University of Pretoria.

“It is an important new subject field for medicine in South Africa and is aimed at medical doctors,” said Dr Louis Holtzhausen, Programme Director of Sport Medicine in the School of Medicine and head of the UFS Sport and Exercise Medicine Clinic.

The course focuses on the wellness and healthy lifestyle of patients and also intercepts the growing need for a specialized medical service for sportsmen,” said Dr Holtzhausen.

Athletes’ needs for specialised medical care have increased dramatically during the past ten years.  “The primary health care practitioner has already surrendered a great deal of the athletics community to disciplines such as physiotherapy, bio kinetics, homeopathy, chirology and other alternative disciplines because of a lack to provide for these practitioners,” said Dr Holtzhausen.

“The course is especially in demand with general practitioners because they want to deliver a more specialized service to patients.  With this course a student can call him/herself a sport doctor and will then not only be able to present patients with scientifically funded exercise, food supplements and advice on their lifestyle, but will also be able to help with the rehabilitation of patients with chronic illnesses,” said Dr Holtzhausen.

“The greatest medical care expense in South African stems from lifestyle bound illnesses such as depression, strokes and obesesiveness.  The M degree in Sports Medicine at the UFS will intercept some of these problems,” said Dr Holtzhausen.

According to Dr Holtzhausen the duration of the degree is three years and it comprises of three legs.  In the first leg, attention is given to an athlete’s performance and how it can be improved with the correct methods and supplements.  In the second leg attention is given to the wellness of patients and the reversibility of the risk of illness and the exercise rehabilitation of chronic illnesses such as diabetes and hart problems to assist patients to exercise in a scientific way in order for them to start living optimally again.  In the third leg attention is given to a healthier lifestyle as a precautionary measure. 

The course also includes a lecture part (four attendance sessions of seven days each) and a thesis.  

“The new course is important for the UFS as the whole tendency in medicine is to move into a direction of a more affordable precaution.  There is no other qualification or programme with as much detail as this course,” he said.

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za
3 February 2006

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