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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UV belê in gehalte met strategiese fokusgroepe - Volksblad
2006-02-09

Verslaggewer
DIE Universiteit van die Vrystaat (UV) gaan vanjaar R10 miljoen beskikbaar stel om sekere van sy akademiese en navorsingsaktiwiteite in strategiese fokusgroepe te bedryf.

 

Volgens prof. Frederick Fourie, rektor en visekanselier van die UV, is hierdie ’n belegging in gehalte wat sal help om die UV nasionaal en internasionaal van ander universiteite in die wêreld te onderskei.

Tydens die amptelike opening van die UV verlede week het Fourie beklemtoon dat die strategiese fokusgroepe veel meer behels as net ’n herorganisering van gevestigde navorsingsgebiede.

“Sulke fokusgroepe behels ’n gefokusde deskundigheidsgebied en nie slegs navorsing nie, maar ook sterk voorgraadse en veral nagraadse onderrig en ’n potensieel sterk wetenskaplike grondslag vir samelewingsdiens.

“Strategiese fokusgroepe sal georganiseer word op die grondslag dat hierdie kennisgebiede op kort termyn die vlagskepe van die UV kan word. Dit beteken dat hierdie die gebiede is waarin die UV nou of in die toekoms waarskynlik ’n kompeterende voorsprong sal hê.”
Hy het gesê dit is belangrik dat die UV hom in die volgende fase van sy ontwikkeling posisioneer, nie net as ’n goeie onderrig- en navorsingsuniversiteit nie, maar ook as ’n universiteit wat in strategies belangrike kennisgebiede uitblink. Dit is noodsaaklik om energie en hulpbronne so te rig.

Nie alle akademiese en navorsingsaktiwiteite gaan egter hierdeur geraak word nie. ’n Breë ondersteuningsgrondslag is die afgelope paar jaar geskep vir uitnemende navorsing deur alle akademiese personeellede in hul eie navorsingsgebiede. Dié inisiatief sal naas die nuwe fokusgroepinisiatief steeds voortgaan.

Fourie sê die strategiese fokusgroepbenadering sal in lyn wees met die benadering wat ontwerp word deur die Nasionale Navorsingsraad (NNR) om nasionale prioriteite in berekening te bring. Breedweg is die vyf strategiese gebiede vir die UV voorlopig die volgende:
1. Voedselproduksie, voedselgehalte en voedselsekuriteit vir Afrika.
2. Ontwikkeling en streeksontwikkeling binne die Afrika-konteks.
3. Maatskaplike transformasie binne die Suider-Afrikaanse en Afrika-konteks.
4. Waterhulpbron- en ekostelselbestuur.
5. Tegnologie vir die toekoms. (’n Aparte fokusgroep rakende die chemiese nywerheid kan dalk bepaal word).

“Binne elk van hierdie gebiede kan ’n aantal nisgebiede geïdentifiseer word. Die fokusgebiede dek sowel die geestes- as die natuurwetenskappe, maar uiteraard kan en moet dit nie alles vir almal probeer wees nie,” sê Fourie.

Die presiese formulering en inhoud van die fokus- en nisgebiede sal nog bepaal word tydens gesprekke op die kampus. Dit sal met die hulp van kundiges buite die UV geskied.
Hy sê dit het sin dat ’n mediumgrootte universiteit soos die UV sy menslike hulpbronne, infrastruktuur, finansiële hulpbronne en intellektuele kundigheid sal konsentreer om te verseker dat ’n bydrae gelewer word tot Bloemfontein, die Vrystaat, die land en die Afrika-vasteland.

Hy sê van die uitvloeisels kan ’n belangrike impak op nywerheidsontwikkeling hê, byvoorbeeld in die chemiese bedryf, en dit mag ook ’n grondslag skep vir samewerking met provinsiale, nasionale en internasionale vennote.

Behalwe die R10 miljoen vir die vestiging van die fokusgroepe is daar die afgelope paar jaar groot bedrae beskikbaar gestel vir talle projekte om gehalte in onderrig en leer, in navorsing en ander gebiede te verbeter.

Berig verskyn in Volksblad - Dinsdag, 7 Februarie 2006

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