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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Counterfeit HIV / AIDS drugs must be dealt with
2006-02-16

Some of the guests attending the lecture were from the left Prof Johan Henning (Dean:  UFS Faculty of Law), Dr Jayasuriya, Prof Voet du Plessis (Head: UFS Department of Mercantile Law) and Dr Ezekiel Moraka (Vice-Rector:  Student Affairs at the UFS).
Photo: Stephen Collett

Counterfeit HIV / AIDS drugs must be dealt with

An international legal expert who has worked with various UN agencies has called on governments to deal quickly and decisively with people dealing in counterfeit HIV / AIDS drugs.

The Vice-President of the Global Jurists Foundation and former head of the UNAIDS secretariat in Pakistan, Dr Dayanath Jayasuriya, was speaking at the University of the Free State in Bloemfontein.

Delivering a guest lecture on HIV/ AIDS and human rights in developing countries, Dr Jayasuriya said counterfeit drugs were spreading at an alarming rate throughout the world.  He said that in particular counterfeit HIV / AIDS drugs contribute to the vulnerability of persons living with HIV / AIDS.

“Only a few countries have integrated anti-counterfeit drug provisions into national legislation on medicinal drugs” he said.
According to Dr Jayasuriya, the violation of the rights of people living with HIV / AIDS is continuing despite the fact that many governments have adopted various charters and declarations that are meant to guarantee the human rights of citizens.

He said these violations have included the brutal murder of persons with HIV / AIDS.

Other violations include verbal abuse and physical injuries through acts of torture; deprivation or denial of access to employment; medical facilities, including drugs; accommodation; food; social service benefits; insurance; custody of children, and so on.

“In recorded human history HIV / AIDS is by no means the first ever major public health epidemic to confront human kind. However, none of the other epidemics generated the same degree and intensity of human rights concerns,” Dr Jayasuriya said.

 

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