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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS seals cooperation with National Institute for Higher Education
2006-03-20

At the signing of the agreement were seated from the left Prof Magda Fourie (Vice-Rector:  Academic Planning at the UFS) and Dr Pearl Nkosi (Head: Academic Planning at the NIHE). Standing from the left were Dr Kopano Taole (acting head of the NIHE) and Mr Vernon Collett (Registrar: Academic Student Services at the UFS).
Photo: Stephen Collett

UFS seals cooperation with National Institute for Higher Education

A formal memorandum of understanding was recently signed between the  University of the Free State (UFS) and the National Institute for Higher Education in the Northern Cape (NIHE).

The memorandum was signed to give both institutions a clear understanding of the way in which collaborative programmes should be implemented.

“Although the UFS has been presenting two bachelors degree courses (i.e. B Soc Sc in Human and Societal Dynamics and B Com in General Management) and the Career Preparation Programme at the NIHE since 2003, the cooperative agreement was never formalised,” explained Prof Magda Fourie, Vice-Rector:  Academic Planning at the UFS, during the signing ceremony.

These academic programmes, presented by facilitators living in Kimberley and lecturers from the UFS, serve 270 students and the entry requirements of the programmes are determined by the UFS.

Prof Fourie said the UFS had a history of a relationship with the NIHE.  The partnership should be seen as an example of how two institutions of higher learning can work together to serve the needs of the students in the region.

“The memorandum of understanding is part of the UFS’s commitment to and engagement with the central region.  As the NIHE is currently operating in a policy vacuum, the memorandum is underpinned by certain principles aimed at providing some parameters within which the relationship is established and developed,” she said.

Dr Kopano Taole, acting head of the NIHE, added to this by saying that the understanding of where the NIHE wants to take the partnership is now reflected in the memorandum of understanding. 

“The memorandum is the culmination of many years of hard work and of helping the people of the region.  The continued input and guidance of the UFS is of tremendous help to us and through this we gained a greater sense of what the NIHE can grow to be,” he said.

The NIHE is a joint initiative of the BHP Billiton Development Trust (BBDT) and the Northern Cape Provincial Government and was established in June 2004.  The National Plan for Higher Eduation (NPHE 2001) proposed the establishment of the NIHE in the Northern Cape to serve as the administrative and governance hub for ensuring the coherent provision of higher education through programme collaboration between the higher education institutions operating in the Northern Cape.

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za
20 March 2006

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