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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS honours many during Autumn Diploma and Graduation Ceremony
2006-04-06

The University of the Free State (UFS) will award 857 diplomas and 2 579 degrees on 21 April 2006 and from 24-26 April 2006 during this year’s autumn diploma and graduation ceremony.  Students from the Main Campus and Vista Campus will take part in the ceremony.   

Altogether 35 doctorates and two honorary doctorates will be awarded.  The honorary doctorandi are Mr Pieter Cox (Ph D (hc)) and Mr Terry Moss (Ph D (hc)).  Mr Cox is the non-executive chairperson of Sasol Limited and Mr Moss is General Manager:  Generation Business Enhancement at Eskom.

On 21 April 2006 at 08:30 altogether 347 diplomas in all the faculties (except the upgrading programmes in the School of Education) will be awarded.  On the same day at 14:30 altogether 361 degrees in the Faculty of Economic and Management Sciences (excluding B Acc, B Admin, B Pub and related honours, master’s and doctor’s degrees) will be awarded.

On 24 April 2006 at 08:30 altogether 510 diplomas will be awarded in the School of Education (ACE, NPDE and CE).  That same day at 14:30 altogether 314 degrees, one doctorate and one honorary doctorate will be awarded in the Faculty of Economic and Management Sciences (i.e. B Acc, B Admin, B Pub and related honours, master’s and doctor’s degrees).  The honorary doctorate will be awarded to Mr Pieter Cox during this ceremony. 

Mr Cox will be honoured for being the driving force behind Sasol’s global expansion and the subsequent listing of Sasol on the New York Stock Exchange.  His passion and focus ensure that Sasol as a national asset is constantly making history, despite the sometimes hostile economic and environmental influences.

On 25 April at 08:30 altogether 325 degrees and 9 doctorates will be awarded in the faculties of Health Sciences, Law and Theology.  That same day at 14:30 altogether 554 degrees, 13 doctorates and one honorary doctorate will be awarded in the Faculty of Natural and Agricultural Sciences.  The honorary doctorate will be awarded to Mr Terry Moss during this ceremony.

Mr Moss is regarded as a modern-day South African industrialist.  He will be honoured for his dedication to the provision of sustainable renewable energy to the citizens of South Africa and Southern Africa through the development and promotion of the hydroelectric power industry and other sources of renewable electrical energy.

On 26 April at 08:30 altogether 427 degrees and 5 doctorates will be awarded in the Faculty of the Humanities and that same afternoon at 14:30 altogether 598 degrees and 7 doctorates will be awarded in the School of Education.

Both the diploma and degree ceremonies will be held in the Callie Human Centre on the Main Campus in Bloemfontein.

Media release
Issued by: Lacea Loader
Media Representative
Tel:   (051) 401-2584
Cell:  083 645 2454
E-mail:  loaderl.stg@mail.uovs.ac.za 
5 April 2006

 

 

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