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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Old Mutual Investment Group invests in our students

2013-07-22

Old Mutual Investment Group’s Imfundo Trust scholars with Mr Muhammad Brey (far left) and Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS (far right).
Photo: Hannes Pieterse
22 July 2013

“I am one step closer to entering the corporate world as a young woman. My dream is to work for a large firm and now it is possible,” said Melody Motaung, a B Accounting first-year student. She is one of the first recipients of the Old Mutual Investment Group’s Imfundo Trust scholarship, which was launched at the university recently.

Melody is one of seven Kovsies and 91 students countrywide to benefit from the R20 million trust, aimed at empowering black professional people in the financial sector. Kovsies is now one of eight universities whose students benefit from the trust. It already empowers students from the University of Johannesburg, UNISA, Nelson Mandela Metropolitan University, University of the Western Cape, University of Fort Hare, Stellenbosch University and Rhodes University.

”The UFS embodies the excellence and innovation we are looking for in tertiary institutions,“ Mr Muhammad Brey, trustee of the trust, said during the launch. He conveyed that the main aim of the trust is to address the shortage of black professional investors in South Africa and to expand the source of suitably qualified individuals in the asset management industry.

The seven recipients, all of them female first-year students, were encouraged by the speakers to do their part in addressing South Africa’s skills shortage in the financial sector.

Prof Hendri Kroukamp, Dean of the Faculty of Economic and Management Sciences, said with the assistance of the Old Mutual Investment Group, the students – four of them B Accounting students – will help to address the shortage of chartered accountants in the country. “As qualified financial experts, they can make a big contribution.”

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