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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

‘Celebrating the music of our times’

2013-07-25

25 July 2013

The Odeion School of Music’s (OSM) New Music Week, hosted from 17–20 July 2013, offered an experience of profundity.

This was the second week-long festival of its kind to be hosted by the OSM – last year the 90th birthday of the South African composer, Stefans Grové, was celebrated with concerts and a symposium. This year the New Music Week focused on the visit of Ensemble Trans-Z under the artistic leadership of former OSM student, Alfred Vorster, a composer living in Zürich. The Order of the Odeion School of Music was bestowed upon Vorster during the festival. The members of the ensemble are the Belgian pianist Lukas Huisman, Danré Strydom (currently an OSM doctoral student in clarinet, based in Ghent), the Argentinian violinist Juan Braceras and the Swedish cellist Karolina Öhman (both currently living in Basel, Switzerland).

The week included three lectures. Lukas Huisman elucidated his doctoral project, Alfred Vorster offered an analytical perspective on the work of Helmut Lachenmann and Hannes Taljaard (Potchefstroom) delivered a commentary on his own composition practice. In addition to presenting masters’ classes in their individual instruments, Ensemble Trans-Z also hosted two workshops – one for the Mangaung String Project and another for OSM students and staff. These workshops focused on creative improvisation practices within an avant-garde style.

The highlight of the festival was two gala concerts that were held on 19 and 20 July. The first concert was hosted by Ensemble Trans-Z themselves, with a selection of compositions in the avant-garde style. The programme included challenging listening material and was creatively presented with unconventional lighting techniques and visual material.

The concert on 20 July consisted of New Music of a more conventional nature. The Odeion String Quartet offered a varied presentation which consisted of a rich mix of talent. OSM postgraduate students Marianne Cilliers, Karol Legierski and Eljee du Plooy formed part of this spectacular performance. The OSM flute lecturer, Handri Loots and the members of Ensemble Trans-Z supplied additional depth to the concert. The experience was made extra special by the recently-formed New Music Ensemble of the School of Music at the North-West University – led by Augusto Arias. Under conductorship of Jan-Moritz Onken, the OSM Camerata completed this impressive collaboration.

The Camerata’s recital of Hendrik Hofmeyr’s Phantom Waltz, which the composer newly arranged especially for this ensemble, was but one of the artistic highlights of an inspiring presentation.

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