Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

International ties for OSM
2013-08-21

 

Prof Nicol Viljoen in the historic Teatr Zdrojowy in Walbrzych, Poland
20 August 2013


Profs Nicol and Martina Viljoen from the Odeion School of Music (OSM) recently undertook a very successful trip to Europe where Prof Nicol Viljoen rendered two solo piano recitals in Poland. They also delivered a joint paper at a congress in Budapest.

The first of the two recitals were held in Crakow at the famed Zespol Panstwowych School of Music. At this event, Prof Viljoen essentially recited Chopin Mazurkas and was invited to repeat this performance in Poland in the future.

The second piano recital was in the historicTeatr Zdrojowy im. Henryka Wieniawskiego in Walbrzych. This concert included Preludes, Mazurkas, as well as the Ballad in G minor by Chopin. After the Mazurkas, the audience rewarded Prof Viljoen with a standing ovasion – and again at the end of the concert. As a result of this, the chief organiser of the event, Jerzy Kosek, who is also the conductor of the Filharmonia Sudecka, invited Prof Viljoen to perform as soloist with his orchestra next year.

Kosek also invited Conducting students at the OSM to work with the Filharmonia under his leadership on an exchange basis. He indicated that he would like to strengthen the ties with the University of the Free State and the Odeion School of Music. Two members of the Filharmonia Sudecka are currently doctoral students in Performing Arts at the OSM, namely Karol Legierski (concertmaster) and Marianne Cilliers (first violin), while the co-concertmaster, Dorota Graca, is in the process of registering for doctoral studies at the OSM.

The paper delivered by Profs Viljoen in Budapest, formed part of the interdisciplinary congress, ‘The Arts in Society,’ where more than twenty countries were represented. Their paper dealt with the post-apartheid oeuvre of the South African composer, Hans Huyssen. Charla Schutte, another doctoral student at the OSM, delivered a paper on an interpretation of indoctrination songs on the basis of an analytical model by the philosopher Johann Visagie.

During the trip, Prof Martina Viljoen also had a productive meeting with the executive manager of Common Ground Publishers, an academic publisher based in the USA, with a view to publish work from the OSM.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept