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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University publishes its Integrated Report
2013-08-23

23 August 2013

The university is proud to have published an integrated report in line with the King III requirements on corporate governance. The university is one of the first universities – if not the first – in South Africa to do so. The UFS sees integrated reporting as a public process through which we report to all our stakeholders, using evidence-based data, on the achievements and challenges of a public university.

Our first Integrated Report reviews the overall performance, non-financial and financial, of the UFS for the 2012 academic year. It is the first report of its kind delivered to stakeholders and guided by the King III framework which recommends integrated, sustainable performance that is reported in a way that enables stakeholders to make an informed assessment of an institution.

The Integrated Report notes that the conditions under which higher education institutions operate have become more demanding in the last two decades and there is a growing need for universities to be more explicit and transparent about the manner in which their core functions (teaching, research and public duty), as well as its administrative operations, are defined by and support good governance, sustainability and corporate citizenship.

The university welcomes this opportunity to present in public an integrated account of itself. In particular, the UFS sees this report as an opportunity to align more strongly its financial and non-financial reporting in pursuit of organisational sustainability and social transformation in South Africa.

Prof Jonathan Jansen, Vice-Chancellor and Rector, notes in the report that in the past four years the university has made significant progress in respect of its two foundational commitments, the Academic Project and the Human Project.

There are now more students entering the university who satisfy the higher requirements set for admission. “This will improve the throughput and graduation rates of incoming students, ensuring their personal success and satisfaction with higher education.” The establishment of a state-of-the-art Postgraduate School, for example, is expected to increase the number, quality and success rates of postgraduate students.

The research output has increased steadily and the contribution of the new Senior Professors project, as well as the five research clusters, have helped to improve the quality of research and the spread of postgraduate recruitment beyond South Africa.

On transformation, the Vice-Chancellor observes that “We have made significant progress in building inclusive, democratic and embracing campus cultures which affirm the value and dignity of all students and staff. With the steady increase of black students in a majority black campus, our goal remains to retain our diversity in a university that serves as an experiment in teaching students to live and learn and love together.”

Financial sustainability is a major commitment and the UFS has not only maintained its record of unqualified audits, but has steadily built a culture of risk management and performance evaluation throughout the system. Internal auditing is a strong instrument in our arsenal to secure financial and operational compliance in every department of the university.

“What integrates the systems and functions of the university is the alignment of everything we do with our two pillars, the Academic and Human Projects, built on a solid foundation of professional support services as described in the Strategic Plan adopted in 2012. In the process of preparing the Integrated Report we discovered how much still needs to be done to align the still disparate and independent activities of the three campuses, seven faculties and more than 100 departments of this large university,” according to the Vice-Chancellor.

The report is available at: http://www.ufs.ac.za/content.aspx?id=184.

 

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