Latest News Archive

Please select Category, Year, and then Month to display items

PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Degree in Forensic Science for 2014

2013-08-28

A BSc degree in Forensic Science will be presented for the first time at the University of the Free State (UFS) from 2014. It is also the first degree of its kind to be presented in South Africa.

According to the Department of Genetics in the Faculty of Natural and Agricultural Sciences the three-year degree is, among others, aimed at people working on crime scenes and on criminal cases in the SA Police Service and in forensic laboratories. At postgraduate level, students can specialise in a variety of forensic fields up to PhD.

A maximum of 80 students will be selected for admission to the course in 2014. Entrance requirements are an admission point of at least 34, as well as a combined minimum point of 17 for Mathematics, Life Sciences and Physical Science. Applications for 2014 close on 30 September 2013. About 700 to 800 new appointments were advertised in this field by the SAPS in the past two years.

The UFS has been offering an honours programme in Forensic Genetics since 2010.

The new course comes at a time when the Government is taking significant steps to eradicate crime in South Africa. At the first conference of the SA Police Service’s National Forensic Service in July 2013, it was reported that milliards of rand are spent to establish an integrated, modernised, well-manned and well-managed criminal justice system. New laboratories are already operational and more laboratories are planned, including one in each province.

The so-called DNA Bill is likely to be approved by Parliament before the end of 2013. Under this bill, all current schedule-1 criminals and suspected criminals will be obliged to provide DNA samples. This information will be stored in a DNA database.

According to the SAPS’ Serial Unit, approximately 1 300 serial killers are currently active in South Africa and the DNA database can be helpful to bring these and other criminals to book. About 80% of all crimes are committed by about 20% of the criminals.

More information on the Forensic Science degree can be found at forensics@ufs.ac.za or +27(0)51 401 9680 or +27(0)51 401 2776.

Issued by: Lacea Loader
Director: Strategic Communication

Telephone: +27 (0) 51 401 2584
Cellphone: +27 (0) 83 645 2454
E-mail: news@ufs.ac.za

Back

Economic and Management Sciences

Education

Health Sciences

The Humanities

Law

Natural and Agricultural Sciences

Theology and Religion

Open Distance Learning

Business School

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept