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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

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President of Spelman College delivered Second Annual Reconciliation Lecture

2013-08-12

Dr Beverly Daniel Tatum
12 August 2013

Dr Beverly Tatum lecture (pdf)
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The United States have much to learn from South Africa about reconciliation. This is according to Dr Beverly Daniel Tatum, president of Spelman College, the oldest college for African American women in the US. Delivering the Second Annual Reconciliation Lecture on our Bloemfontein Campus, Dr Tatum –an internationally-acclaimed educator and expert on race relations –said five years after the US elected its first black president, the country still finds it difficult to make peace with the painful truth of its past.

Drawing inspiration from a speech made by former president Nelson Mandela at the adoption of the South African constitution in 1996, Dr Tatum said it requires courage to engage in a meaningful way with those we have been socialised to mistrust.

Dr Tatum highlighted the shooting of the US teenager Trayvon Martin, who was killed in Florida in an incident many attributed to racial profiling. The unarmed Martin, while out walking in the evening to buy a snack, was accosted and shot by neighbourhood watchman George Zimmerman who suspected him to be a potential thief.

“How do we move beyond stereotypes to more authentic knowledge of one another?” she posed the question to a packed Reitz Hall in the Centenary Complex.

Dr Tatum, author of the critically-acclaimed books, Can We Talk about Race? and Why Are All the Black Kids Sitting Together in the Cafeteria? said we have to be brave enough to have our assumptions challenged.

“If we want a better society, one characterised by strength, trust and unity, we must interrupt the cycle and there is no better place to do it than at a university like this one, where the next generation of leaders is being prepared. But it requires intentionality. It takes practice.”

During her two-day visit, she also met with postgraduate students from the Faculty of Education to discuss social cohesion at schools. She also took part in a roundtable discussion with educators from the UFS and other universities, deliberating the topicLeading with/for/against differences on university campuses.

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