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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS arts are experiencing a boom
2013-09-03

 
Dot Vermeulen
3 September 2013

The arts at the University of the Free State are experiencing a boom, with several Kovsie artists achieving on a national platform. Dot Vermeulen, a junior lecturer in the Department of Fine Arts, is the latest UFS artist to be honoured nationally as the winner of the 2013 Sasol New Signatures art award. 

The award is rewarding emerging young artists. The winning entry, entitled “Desperately disciplined,” by Vermeulen, who is currently studying toward her master’s degree in Visual Arts, was chosen from approximately 400 entries. 

Earlier this year, Pauline Gutter, a former Kovsie, won the Absa L’Atelier competition, which is South Africa’s most prestigious art competition. The year before, another former student from our Department of Fine Arts, Elrie Joubert, won the competition. 

Vermeulen says there are brilliant people at the UFS who are active in visual arts at various levels. "People such as Janine Allen-Spies (lecturer in painting) and Angela de Jesus (curator of the Stegmann gallery) are not only good artists, they are also involved with the community and invest a great deal of energy into the development of young artists. From my own experience, I can say that I have benefited a lot from academic scholarships from the UFS in the course of my study career." 

She says her winning entry refers to the relationship between traditional tactile painting and contemporary digital media. "The focus is especially on hidden moments of absorption and correspondence during the art-making process. The painting installation depicts a reading nude figure on a couch. A computer screen is mounted on a stand in front of the painting, animating the same image, while at the same time blocking the view of the painting. In the animation, the nude figure pages through her book from time to time, with the paint and digital drawing marks moving around her. The text “Envoi is typing…” is also animated on the surface of the couch repeatedly. It is suggestive of internet chat boxes, which often pop up on the screen while I am working on my laptop." 

As winner of the Sasol New Signatures art award, Vermeulen won R60 000 and the opportunity of a solo art exhibition in the Pretoria Art Museum. 

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