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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University is proud of its women in science
2013-08-17

 

Dr Marieka Gryzenhout
Photo: Sonia Small
19 August 2013

Two lecturers in the Department of Plant Sciences received national recognition for their research at the Women in Science Award 2013 function of the Department of Science and Technology (DST) on Friday 16 August 2013. Dr Marieka Gryzenhout received the award as Young Women Scientist and Prof Maryke Labuschagne was first runner-up in the category Distinguished Women Researcher, both in Life Sciences.

The third award-winner was Rose Lekhooa in the Doctoral Fellowship category. She is studying toward a PhD in Pharmacology and said the fellowship will enable her to attend seminars and workshops internationally.

Friday’s award was the second, in as many months, for Dr Gryzenhout. She received the TW Kambule NRF-NSTF Award as emerging researcher in June 2013. She was the recipient of the International Union of Forestry Research Organizations’ Outstanding Doctoral Research award in 2010.

Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, said, “Dr Gryzenhout represents one of a growing group of very impressive young scientists at the university who are emerging as leading international scholars in their fields.

“Her international leadership in mycology research has already made significant impacts on the African continent and beyond. The university will continue to invest in these young academic stars through its Prestige Scholars Programme where scholars like Dr Gryzenhout are increasingly well-placed to be the next generation of scientific leaders in the world.”

“It as a great privilege to receive the award, especially as second one in this year,” Dr Gryzenhout said. She established a research programme, Mycotoxigenic and Phytopathogenic Fungi, at the UFS. She is president of the African Mycological Association and general secretary of the International Society for Fungal Conservation. She is also a member of the Nomenclature Committee for Fungi – a permanent committee of the International Botanical Congress.

Prof Labuschagne received the African Union Kwame Nkrumah award for life and earth sciences in 2011, and the National Agriculturalist of the Year Award and the National Science and Technology Forum (NSTF) Award for research-capacity development over the last five to ten years, both in 2008.

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