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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University tips its hat to final-year students
2013-09-13

 
From the left: Lauren Marais, Werner Landman, Herloise Jordaan and Louis Rossouw (PwC).
13 September 2013

The Alumni Office at the University of the Free State (UFS), in partnership with PricewaterhouseCoopers (PwC), held its first Alumni Evening for final-year students.

The students received valuable advice from various speakers during the event. Werner Landman – also a UFS graduate – highlighted the differences in approach between the current and previous generations. Landman explained that Generation Y students have greater influence and are extensively connected socially as they enter the work environment. “You are people who will work to live, unlike us, Generation X, who live to work,” he said. With their degrees – some already busy with their post-graduate studies – they are more likely to be appointed in professions which will allow them to live better, he added.

Heloise Jordaan, former 2008/9 SRC president, who holds three degrees from Kovsies to her name, also addressed the final-years. She currently holds the position of brand manager at Urban Hotels, although she only started working recently. Through sharing her personal work experiences, she gave the audience a glimpse into the workplace."You guys need to realise that when you step into the working sphere, you need to be open minded and also work to the best of your abilities,” Jordaan encouraged.

The evening was concluded on a high note with a prize-giving. Pieter du Toit, UFS Alumni Chair, was in charge of handing over the awards. Residences were compared to find which ones generated the most residing final-year and postgraduate students. House Tswelopele and Soetdoring clinched the honours and walked away with R2 000 each for their house.

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