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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

'England, the English and the problem of education in South Africa.’

2013-09-26

Attending the lecture were, from the left: Dr Susan Brokensha, Senior Lecturer: Department of English; Prof Rosemary Gray, Professor Emeritus (Honorary Life Vice-President of the English Academy of Southern Africa); Prof Jonathan Jansen; and Dr Thinus Conradie, Lecturer: Department of English.
Photo: Johan Roux
26 September 2013

Prof Jonathan Jansen: Lecture

The university celebrated the life of one of South Africa's most renowned art critics, hosting the 2013 English Academy’s Percy Baneshik Memorial Lecture on the Bloemfontein Campus.

The keynote lecture was delivered by Prof Jonathan Jansen, Vice-Chancellor and Rector, who joined a distinguished list of speakers to have delivered the lecture. Presented annually by the English Academy of Southern Africa, an association dedicated to promoting the effective use of English as a dynamic language in Southern Africa, past speakers include Prof Es’kia Mphahlele, Prof Njabulo Ndebele, Dr Alan Paton and Prof Albie Sachs. The lecture is hosted at venues across the country and this year Bloemfontein paid tribute to Percy Baneshik.

In his speech Not even colonial born: England, the English and the problem of education in South Africa,' Prof Jansen addressed the dilemma of the politics of language in both school and university education today.

Talking about the dominance of English in schools, Prof Jansen said it is the language of choice because indigenous languages are so poorly taught. "Simply learning in your mother tongue is absolutely no guarantee of improved learning gains in school. The problem is not the language of instruction; it is the quality of teaching, the knowledge of curriculum and the stability of the school."

Prof Jansen told the audience in the CR Swart Hall that Afrikaans-exclusive, or even Afrikaans-dominant white schools represent a serious threat to race relations in South Africa. "You simply cannot prepare young people for dealing with the scars of our violent past without creating optimal opportunities in the educational environment for living and learning together."

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