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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Students learn how to prepare for the workplace
2013-10-18

Attending the information session were, from the left: Shelagh Foster and Phiwe Mathe, SRC president of the Bloemfontein Campus. 
18October 2013
Photo: Johan Roux

  Your First Year of Work: YouTube video

Getting a foot in the door with potential employers is a struggle for the inexperienced, more so for fresh out of school graduates who don't know how to put a CV together, can’t spell or dress properly when meeting employers. 

Launching her book Your First Year of Work: A Survival Guide, communications expert Shelagh Foster highlighted  these facts and others during an information session on the Bloemfontein Campus. Students who attended gained a wealth of information from her and Prof Jonathan Jansen, Vice-Chancellor and Rector, who shared tips on how to prepare for the workplace and be successful in their job search. 

Shelagh explained how a request from a graduate to do an internship at Media Online, where she had formerly worked as editor, made her decide to teach jobseekers the basics of verbal and written communications. She told the audience that the e-mail request from a female student, was littered with mistakes and left her with questions such as "what if she is really smart, has something to offer the company, but just don't know how to send an e-mail?" 

Practical advice she gave, include dressing properly for a job interview, knowing who you communicate with when addressing an e-mail, as well as finding out as much as possible about the company you are applying to. 

* Your First Year of Work: A Survival Guide  addresses the unwritten codes that exist in the workplace that need to be understood by interviewees and new employees battling to get ahead once they've finished with matric or university. 

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