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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Institute launches Human Rights Desk
2013-10-22

 

Attending the launch of the first Human Rights Desk were from left: Prof Teuns Verschoor, former Vice-Rector: Institutional Affairs, Dr Leon Wessels, human rights activist and lawyer, and Dr Choice Makhetha, Vice-Rector: External Relations.
Photo: Huibrecht Hoffman
22 October 2013

The university has created another beacon for social justice and reconciliation with the launch of its first Human Rights Desk (HRD) on the Bloemfontein Campus. The HRD, which falls under the Institute for Reconciliation and Social Justice, will promote, protect and monitor human rights at the university.

Speaking at the launch of the HRD, Prof Andre Keet, Director of the Institute for Reconciliation and Social Justice, said the desk will investigate reported violations of human rights on campus. "It will investigate any cases that require investigation, as well as various other projects that serves the university and national and international imperatives as far as human rights is concerned.”

Prof Keet told students and staff in attendance that the desk is an expression of the university's commitment. "As a university, we have to own this particular desk, as a collective entity we should make it work and be proud of it. Our task is to build a new form of productivity into the language of rights, and build a culture of human rights among our students, which we can already see emerging."

Also speaking at the event, Prof Jonathan Jansen, Vice-Chancellor and Rector, said the HRD will be a place where people can come who are hurt. He encouraged students to speak on human rights anywhere in the world. "I want you to think of yourself as a borderless human being, for human rights are not geographically confined. I want you to also hurt when somebody in a mall in Kenya gets hurt."

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