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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

National accolade for Dr Philemon Akach

2013-10-21

Dr Philemon Akach
Photo: Sonia Small
21 October 2013

Excellence in Teaching and Learning is highly regarded at the University of the Free State, with our academics recognised on national and international platform.

Earning yet another accolade for the university, Dr Philemon Akach, Head of the Department of South African Sign Language, has been awarded a National Excellence in Teaching and Learning Award. The award by the Higher Education Learning and Teaching Association of Southern Africa (HELTASA) and Council on Higher Education (CHE), recognised Dr Akach as a “leader in the field of teaching and learning – with impact beyond the classroom and the institution.” Recognising his pioneering work within deaf education, HELTASA and CHE commend Dr Akach as an “inspirational practitioner who recognises the inclusion of the marginalised in education.”

Dr Akach is one of five recipients, selected out of a total of 22 candidates from across South Africa that will receive the award. The other winners are from the University of Cape Town, Stellenbosch University, University of KwaZulu-Natal and the University of Pretoria. The five winners will receive the awards at a gala dinner at the annual HELTASA conference, which takes place from 26 to 29 November 2013.

Dr Akach, who will retire at the end of 2014, says the national recognition is the cherry on top as he prepares to return to his home country. Kenya. “How good can it be?” “This is my life calling,” he said about the 37 years he worked within deaf education.

The academic also received an Alumni Award for Outstanding Service at the recent Kovsie Alumni Awards.

Pioneering work by Dr Akach:

With Dr Akach steering the process, the UFS became the first university on the continent to offer Sign Language as an academic course in 1999.
Dr Akach was part of a nine-member task team that handed over the South African Sign Language (SASL) curriculum to the Minister of Basic Education, Angie Motshekga. A member of the ministerial task team since 2009, he helped to coordinate the development of the curriculum that will soon be offered as a school subject to Grade 0–12 learners in all 42 schools for the deaf in South Africa.

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