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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Well-known alumni honoured

2013-10-24

From the left are: actor Hannes van Wyk, Judge Faan Hancke and his wife Benita at the Kovsie Alumni Awards.
Photo: Elmada Kemp
24 October 2013

The actor and film maker, Hannes van Wyk, known for his role as Krynauw du Boisson in the M-Net soapie Egoli, was named Kovsie Alumnus of the Year during the Kovsie Alumni Awards. He and six other former Kovsie students and staff were honoured at this gala event for their outstanding achievements and contributions to the UFS during 2012.

Van Wyk, who completed his BAEd in 1990 at the University of the Free State, was honoured for his contribution to, and development of the South African Film and Television industry. This includes his work as producer, writer, researcher and director of companies such as PACOFS, M-Net and the SABC.

The actor wasn’t the only person in the public eye to be celebrated at the event.

The well-known columnist, Hanlie Retief, who interviews the top newsmakers of the country every week for Rapport, was recognised with a Cum Laude Award. She was honoured in this category together with Paul Colditz, Chief Executive Officer of FEDSAS, the national representative organisation of governing bodies, and Judge Violet Phatshoane, founder of Phatshoane & Henney Attorneys and judge in the High Court of South Africa.

Hanlie told the audience that her degree from Kovsies opened doors for her. She spoke about the interview she had in those days with the athlete Zola Budd, her first story to be published in the university publication, Bult.

Prof Johan Willemse, who is internationally known as an agricultural economist, and Dr Philemon Akach, known for his contribution to the development of Sign Language on the continent, were bestowed with the Alumni Award for outstanding service to the UFS.

The Kovsie Ambassador Award was presented to Judge Faan Hancke, Extraordinary Professor in the Faculty of Law at the UFS. As a former Kovsie, he served more than 12 years as Council member during his career and is still involved with the Alumni Trust.

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