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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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UFS and DRC Free State sign cooperation agreement
2013-11-27

The University of the Free State (UFS) recently signed a cooperation agreement for a period of five years with the DRC Free State. In this contract it is agreed that the university will offer theological training to DRC ministers.

With this agreement, the DRC Free State confirmed that the theological training currently offered by the Faculty of Theology meets the requirements and expectations of the church in such a way that her ministers can be trained within this context and ethos of the UFS. The Faculty of Theology believes that church involvement in the training of students of the DRC FS (as with all other churches), as well as the spiritual formation and guidance of those students, are important during their training and should be retained.

According to Prof Driekie Hay, Vice-Rector: Academic, the Faculty of Theology at the UFS is the only institution in Central South Africa that offers complete and comprehensive theological training.

“As the youngest of the faculties at the UFS, this faculty has developed a lot in a relatively short time and is firmly established on many levels. The faculty currently offers training in all theological disciplines, from undergraduate to PhD level,” says Prof Hay.

The Faculty of Theology offers a unique national and international contribution to the development of the church, society and academic theological environment. This is made possible through quality theological training and specialist research based on a framework of classical theological training and research.

The new cooperation agreement that was signed acknowledges the uniqueness and independance of both the DRC in the Free State and the Faculty of Theology as public institutions, and strives to serve the interests of both institutions best.

According to Prof Fanie Snyman, acting Dean of the Faculty of Theology, this new agreement proves that the UFS is not only training students academically, but is also concerned with the human aspect of its students.

“It is a privilege for the university to be associated and work together with the DRC in this way,” says Prof Hay. Rev Jan Lubbe, Moderator of the DRC Free State, also indicated that he is very positive and excited about the new agreement.

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