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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS invests in community journalists
2013-12-09

The first group of journalists who completed the Department of Communication Science’s short-learning programme for community journalists. The course was developed by Mrs Willemien Marais (far left) and Mrs Margaret Linström (far right). In front in the middle are Prof Lucius Botes, Dean of the Faculty of the Humanities, and Mr Lumko Mtimde, CEO of the Media Development and Diversity Agency, the sponsor of the programme. Fifth from right is Ms Manana Monareng Wa Stone, Programme Manager of the MDDA.

An investment in our people, our region and our democracy. This is the value of the Department of Communication Science’s short-learning programme for community journalists.

The first 20 community journalists from radio stations and newspapers in the Free State and Northern Cape received their certificates recently after successfully completing the course Basic Journalism Skills for Community Media.

This credit-bearing short-learning programme is fully sponsored by the Media Development and Diversity Agency (MDDA), a statutory body with the aim of developing and promoting community media.

The University of the Free State (UFS) is the first university in South Africa that presents a course of this nature. “It is also the first large-scale formal training of community journalists in the Free State and Northern Cape,” says Mrs Margaret Linström, journalism lecturer in the Department of Communication Science. She developed the course together with another journalism lecturer in the Department, Mrs Willemien Marais. “What distinguishes our programme for similar programmes is the element of mentoring,” explains Marais. Students attend a week-long training session on the Bloemfontein Campus of the UFS. The lecturers then visit all the participating newsrooms to provide further training in terms of the unique challenges of their area. “During the second semester we’ve travelled more than 3000 km to visit radio stations and newspapers as far afield as Springbok and Phuthaditjhaba,” says Linström.

During the certificate ceremony the CEO of the MDDA, Mr Lumko Mtimde, said this partnership with the UFS has the potential to make a tangible difference in communities. “Combined community media reaches the largest target audience in the country. Against this background the importance of training community journalists becomes very clear,” says Mtimde.

The role of community journalists differ from that of journalists who work for state or commercial media. Yet most of these community journalists fall outside the network of formal training, mostly due to a lack of resources and access to training.

“This course has changed my life. I came back as a newborn baby for whom everything is new!” said Mr Setona Selisa from Naledi FM in Senekal. Selisa and his colleague, Mr Teboho Mabuya, received the award for the best participants of the 2013 course.

 

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