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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

How are children taught about sexuality?
2014-01-05

 

Prof Dennis Francis
How is sexuality taught at schools? More importantly, why is heteronormativity taught at schools?

These are the questions that drive Prof Dennis Francis, Dean of the Faculty of Eduation, in his research on sexuality education.

His extensive research papers point out how schools promote compulsory heterosexuality and that homosexuality is something to be hidden and kept separate from teaching, learning and daily school life.

Prof Francis’ research dates back to the early 2000s, when he became concerned about the high HIV prevalence and other sexually transmitted diseases among 15-25-year-olds and the dropping age of sexual debut, as well as the increase of sexually active teenagers that are not adequately protecting themselves against undesired pregnancies and disease.

It was in the light of this that he started looking at how messages of sex and sexuality were conveyed to adolescents before becoming sexually active.

From 2006 to 2008, he was awarded a Medical Research Council Grant under the MRC research priority area of HIV/Aids.

In the past three years, he has collaborated with Dr Renee de Palma, a leading international European scholar who has published widely on sexuality education, gender and heteronormativity.

Using a National Research Foundation (NRF) grant, they collected data from 25 sexuality educators across the Free State on the teaching of sexuality education. They have published three articles in peer-reviewed journals, one is in press, one book chapter was published and two are currently under review.

Prof Francis says he is also pursuing a research project in the teaching of lesbian, gay, bisexual and transgender education in the sexuality education curriculum.

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