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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

It’s Rag Time!
2014-01-14

 

Zakes Bantwini, Mango Groove and Robbie Wessels 
Photos: Supplied

Kovsie Rag Community Service will start 2014 off with the well-known Rag festivities, with enthusiastic students already starting with float building in January. The theme for Rag CS 2014 is ‘Movies.’

As from 20 January, a cheerful atmosphere will be present at the Kovsie Rag farm, with senior and junior students working hard, while social cohesion is developing between them. Great entertainment will be part of these festivities, with the likes of DJ Euphonik and Adam performing on 31 January.
In the midst of all these activities, the annual ‘Chicken Run’ evening collections will take place on 21, 23 and 28 January, as well as the Ritsim sales in Bloemfontein and surrounding areas on 24-25 January.

The hard work will reach its peak with the judging of the floats on the morning of 1 February, after which the floats will depart at 09:00 for the first procession of the day. This route will end at Twin City Mall at 11:00, where 10 000 meals will be distributed to communities in Heidedal and Mangaung. Learners from Heidedal schools will entertain the public with their talents.

Our very popular family festival will already start at 16:00 with the opening of the gates at Chevrolet Park Cricket Stadium. Young and old will be entertained by well-known and vibrant artists, such as Robbie Wessels, Mango Groove, Zakes Bantwini, as well as a spectacular firework show. Come early to ensure a great spot on the grass.

The float winners will be announced at 17:00, whereafter the main procession of the day will depart from the Tempe robot in Nelson Mandela Drive at 18:00. The public can look forward to this ever popular procession through the streets of Bloemfontein, with decorated floats and students cradling collection tins proceeding to Chevrolet Park. The 2012/2013 UFS Rag queen, Mr Rag and their retinue will greet the public from the main float. Finalists for the 2013/2014 UFS Rag queen and Mr Rag titles, as well as drum majorettes, will also accompany the procession.

Do not miss out on this wonderful family festival – come early, bring your family and picnic blanket/chairs to ensure a great spot on the grass – a variety of refreshments will be on sale.

Tickets available from Computicket and entrance gates.

Tickets: R60 per person
R30 per child under 12

We would also like to make use of this opportunity to remind you of our vibrant 2013/2014 UFS Rag coronation ball, where the UFS Rag queen and Mr Rag CS for 2014 will be crowned on 14 February 2014 in the Callie Human Centre, UFS Campus.

Limited tickets will be available at R500 per couple and can be bought from the Rag Community Service office from 5 February 2014.

Enquiries:

Karen Scheepers +27(0)51 401 2423 ( ScheepersK@ufs.ac.za )
Esmé Wessels +27(0)51 401 3769 ( Wesselse@ufs.ac.za )

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