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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

International speakers unite to discuss diversity
2014-01-20


The Institute of Reconciliation and Social Justice is hosting a two-day colloquium on 30–31 January 2014. A broad range of keynotes will discuss the topic: ‘Diversity and the politics of engaged scholarship: A comparative study in higher education’.

Prof Jonathan Jansen, Vice-Chancellor and Rector, and Prof Dr Halleh Ghorashi from the Netherlands will lead as keynote speakers on the first day.

Prof Dr Ghorashi is a Professor of Diversity and Integration in the Department of Sociology at the Vrije Universiteit Amsterdam. She is the author of ‘Ways to Survive, Battles to Win: Iranian Women Exiles in the Netherlands and the United States’. She has also published extensively on topics such as identity, diasporic positioning, cultural diversity and emancipation.

During the second day, Dr Charles Alexander from Los Angeles and Prof Shirley Tate from Leeds will lead as keynote speakers.

Dr Alexander is Associate Vice-Provost for Student Diversity at the University of California. He has run several programmes for students who have been underserved by higher education, including students from immigrant families and underrepresented populations. In 2011, Dr Alexander received a Champions of Health Professions Diversity Award from The California Wellness Foundation in recognition of his commitment to increasing California’s health care workforce and its diversity.

Prof Shirley Tate’s work focuses, among others, on theorising ‘race’ performativity and the intersection between 'race' and gender. She has written on mixed ‘race’ identities, affect, beauty, embodiment, pain and women in prison, transracial intimacies, gendered prison identities, racial affective economies in organisations, as well as on domestic work and food.

The sessions led by these keynote speakers are open to the public and the Institution welcomes everyone to join in this topical discussion.

Date: Thursday 30 January 2014 and Friday 31 January 2014
Time: 09:00–11:00
Place: Centenary Hall
RSVP: vannestel@ufs.ac.za 

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