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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Ensuring justice does not get lost in translation
2014-02-06


Court interpreters who have successfully completed a legal interpreting learnership.
Photo: Stephen Collett

The University of the Free State (UFS) is a taking a leading role in changing the face and character of the South African court system, infusing it with qualified professionals.

The university’s Unit for Language Facilitation and Empowerment partnered with the Department of Justice and Constitutional Development as well as the Safety and Security Sector Education and Training Authority (SASSETA). This union lead to 63 court interpreters successfully completing a legal interpreting learnership.

These newly-qualified interpreters will from now on render specialised interpreting services in courts across our country.

Addressing the audience at the diploma ceremony held on the Bloemfontein Campus, Dr Derek Swemmer, Registrar of the UFS, said translators have an important role to play. ”Translation is a gift to those who do not understand the language that a person is speaking,” he said.

In her speech, Nonkululeko Sindane, Director-General in the Department of Justice and Constitutional Development, said the qualification will improve the professional status of court interpreting. She added that the learnership is based on a broader government policy on skills development. She mentioned that eight of those who received qualifications have been permanently employed by the department.

Praising the university for its role, Abbey Witbooi, Chairperson of the SASSETA board, said the diploma will allow qualified learners to contribute to social and economic transformation. This will ensure the protection of human rights in the court setting. In addition, it also provides equal access to a fair trial in terms of effective communication. “The fact that this is a first in the republic, speaks volumes for the extent of the commitment of collective leadership to realise the transformation agenda,” he said.


 

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