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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Goodwill and unity reigns supreme at official opening

2014-02-07

Video
Transcription: Prof Jonathan Jansen speech

The academic year at the UFS was officially opened by Prof Jonathan Jansen, Vice-Chancellor and Rector, at a splendid event with staff at the Bloemfontein Campus. “The UFS is no longer the place it was four years ago. When I arrived here, the place was very much divided. The picture is very different today. Staff and students have come together and are spending time together as friends. A new spirit reigns at the university. People are no longer mad at each other; they talk to each other,” Prof Jansen said.

The reason: students know that they are loved and respected. The people responsible for this – the staff.

Prof Jansen particularly emphasised the capacity of staff members to change and to care. “Change at the UFS is possible because of the positive attitude of staff and students. This creates an atmosphere where students can learn to love and forgive.

“We have reached a new consensus where racism, sexism, xenophobia and homophobia are wrong. We also address this bad behaviour immediately.

“Another highlight at the UFS is the changes in the academy. Debate is deeper and more progressive. We have the best intellectual debates at the UFS. We are also proud of our young researchers in the Prestige Scholars Programme. We are excited, because in five years’ time we will reap the fruits from the efforts of young, as well as older researchers who have worked hard so that we can deliver the best researchers.

“There is another shift in the academic culture on campus with our students increasingly looking academically stronger.

“Besides the capacity of staff to change, they also have a capacity for caring. Projects such as the Staff Fund and the No Student Hungry Programme is doing well, with the NSH Programme raising more than R1 million to feed hungry students,” Prof Jansen said.

At this event, Prof Jansen also gave recognition to the team involved with and working very hard at the Schools Change Project, which is largely responsible for the Free State’s good matric results. With the inspiration of the staff involved with this project, a difference is made to schools in the Free State.

“Our staff members do more than is stipulated in their contracts. Our staff members do their jobs from the heart,” Prof Jansen said.

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