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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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SA-YSSP scholars attend high level colloquium with policy makers and research stakeholders
2014-02-12

From the left are: Prof Frans Swanepoel, Deputy-Director of the African Doctoral Academy, Drs Aldo Stroebel, Executive Director: International Relations and Cooperation at the National Research Foundation, Priscilla Mensah, co-director of the SA-YSSP, and Ulf Dieckmann from the International Institute for Applied Systems Analysis and Dean of the SA-YSSP.
Photo: Renè-Jean van den Berg

Scholars taking part in the 2nd Southern African Young Scientists Summer Programme (SA-YSSP), attended a one-week seminar hosted by the African Doctoral Academy at the Stellenbosch University, which concluded with a colloquium at the Stellenbosch Institute for Advanced Study.

This was part of the final leg of their three-month stay and studies at the University of the Free State.

This seminar was a capacity development intervention with the purpose of equipping SA-YSSP young scholars with the skills to communicate their research work effectively with different audiences.

The 36 scholars were hand-picked from some of the world’s most promising and top researchers to take part in the novel three-month programme for advanced doctoral candidates. Their research interests closely aligned with the Department of Science and Technology’s (DST) grand challenges and the International Institute for Applied Systems Analysis’ (IIASA) current research programmes regarding global environmental, economic and social change.

The SA-YSSP is an initiative that contributes to the establishment, growth and enhancement of high-level strategic networks internationally. At the same time it develops capacity in systems analysis at the PhD and supervisory levels through research conducted in the areas of the Department of Science and Technology’s (DST) grand challenges.

At the colloquium, students were expected to showcase their work and research according to their various fields of expertise. High-profile policy makers and policy funders, as well as academia and fellow researchers judged and critiqued the work.

Dr Priscilla Mensah from the UFS and co-director of the programme, says it is important for the young scientists to frame their findings in a way that will be relevant to policy makers and the public at large.

“The partnership with the African Doctoral Academy was crucial in this regard since it is a capacity development entity aimed at strengthening and advancing doctoral education, training and scholarship on the African continent. The objective of this week-long capacity strengthening intervention is to equip the young scientists to be able to communicate their research effectively with different audiences, including potential funders and policy makers.

“I am convinced that the young scientists will no longer view policy makers as abstract entities, but as stakeholders who must be engaged to facilitate implementation of evidence-based policy.”

Dr Aldo Stroebel, Executive Director: International Relations and Cooperation, National Research Foundation, says the purpose of the colloquium is to bring together different sectors in one room to look at different challenges holistically, with an emphasis on systems analysis for a common goal.

The SA-YSSP forms part of an annual three-month education, academic training and research capacity-building programme jointly organised by IIASA, based in Austria, the National Research Foundation (NRF) and the DST. IIASA is an international research organisation that conducts policy-oriented scientific research in the three global problem areas of energy and climate change, food and water, and poverty and equity. South Africa’s engagements with IIASA, specifically with regard to the SA-YSSP, relate primarily to the DST’s Ten-Year Innovation Plan.

The UFS is the first institution outside Austria to host the summer programme. Researchers in the programme are, among others, from South Africa and the rest of the African continent, the USA, the Netherlands, India, Hungary, Austria and Germany.

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