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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

In her inaugural lecture, Prof Helene Strauss explores symbols that reflect our history

2014-02-18

Prof Helene Strauss
The burning tyre – image of promise and disappointment
Photo: Stephen Collett

Prof Helene Strauss did not disappoint in her highly-anticipated inaugural lecture “The Spectacles of Promise and Disappointment: Political Emotion and Quotidian Aesthetics in Post-transitional South Africa”. She posed some very challenging ideas on the promises and disappointments that arouse from apartheid. Prof Strauss pointed to the fact that “… a promise must promise to be kept; that is, not to remain spiritual or abstract, but to produce events, new effective forms of action, practice, organisation, and so forth.”

She underscored the message of her lecture by making use of the image of a burning tyre – a symbol commonly associated with apartheid. This act of ‘necklacing’ is closely connected to the violence and protests of that era. Prof Strauss used this image to represent an array of social concerns: global mass protest, modernity and mobility, waste economies and waste management, environmental destruction, as well as poverty and resistance in varied formats.

Some of South Africa’s greatest artists have used the burning tyre in their work, particularlyBerni Searle and Zanele Muhloi. Not only does it trigger the shadow of the damaging past, but “more recently, it has come to figure also in the spectacles of promise and disappointment that have marked the country’s transitional and post-transitional periods,” Prof Strauss remarked.

Prof Strauss focuses her research on these symbolisms in our history because of “the questions that they raise about the emotional cultures produced in the aftermath of apartheid and for the unique contribution that they make to current debates on political and aesthetic activism.”Her passion for this subject comes from the “affective or emotional legacies of various forms of structural inequality, an interest that owes a sizeable debt to postcolonial, queer and feminist critical theory and creative work of the past hundred or so years.”

Prof Strauss accepted a position at the University of the Free Sate in 2011 and currently works in the Department of English. She is part of the Vice-Chancellor’s Prestige Scholars Programme and holds a PhD from the University of Western Ontario. Previously, she held the position of Assistant Professor in the Department of English and Cultural Studies at McMaster University in Canada, where she resided for 11 years.

Among the guests were Prof Jonathan Jansen, Profs Botes and Witthuhn, lecturers in the Department of English, members of the Faculty of the Humanities, students and some of Prof Strauss’ colleagues from Canada.

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