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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS acts fast in expelling students for serious misconduct

2014-02-22

On the evening of Monday 17 February 2014, Muzi Gwebu, a fifth-year student in BCom Economics, while walking on the Bloemfontein Campus of the UFS, was side-swiped by a vehicle driving recklessly through campus. He followed the vehicle where it stopped at one of the residences and approached the two occupants. A confrontation started and he was assaulted by one of the occupants of the vehicle.

Gwebu sustained minor injuries and was immediately assisted by the university’s residence life division. He lodged a complaint of assault at the South African Police Service (SAPS).

The senior leadership of the UFS is shocked and outraged at this blatant act of violence against one of its students. The Vice-Chancellor and Rector, Prof Jonathan Jansen, says: “We regard this incident in a very serious light and we worked closely with the SAPS throughout the night to identify and locate the perpetrators who were driving with false number plates.”

With the assistance of the student leadership in one of the residences, the owner of the vehicle and his companion were traced this morning.

The two students were immediately handed to SAPS by the university’s Protection Services and were arrested on charges of attempted murder, assault and driving with false number plates.

In addition to the criminal investigation by the SAPS, the university is also conducting an urgent and formal investigation into the incident.

The university has offered Gwebu full counselling and support until he is fully recovered.

“It is sad and disappointing that, after so much progress with the social transformation of the UFS, such a horrific incident could have occurred. It is pleasing, however, that across the board, all our students condemned these vicious acts. The students, if found guilty in the criminal and institutional investigations, will definitely not be allowed to study at the University of the Free State,” he said.

END

Statement by Dr Willy Nel, Residence Head of Armentum men’s residence

The Residence Head, Residence Committee and all residents of Armentum male residence on the Bloemfontein Campus unequivocally distance themselves from any behaviour which does not breathe the letter and spirit of the University of the Free State's vision of Human Embrace and Academic Excellence. We work tirelessly to upend traditions that are contradicting this vision. Therefore we add our voice to those who condemn the incident in which ex-residents allegedly assaulted a pedestrian who is also a student of our institution. We express our support to and confidence in the university's and other processes to find justice in this matter.

Dr Willy Nel
Residence Head: Armentum

Media release
Lacea Loader (Director: Communication and Brand Management)
Tel: +27(0)51 401 3422
Cell: +27(0)83 645 2454
E-mail: news@ufs.ac.za

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