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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Deputy Minister leads a space science outreach programme in Bloemfontein

2014-02-28

The Deputy Minister of Science and Technology, Michael Masutha and Mandla Maseko– the first black South African expected to go into space in 2015 – will participate in a Space Science Outreach Programme at the University of the Free State on Saturday 1 March 2014.

The event, taking place at the Bloemfontein Campus, is part of an outreach programme to raise awareness about South Africa’s advances in space science and technology and its benefits to society.

Mr Maseko will share his exciting experiences in the Axe Apollo Space Academy competition, a challenging event that included skydiving, aptitude tests and building and launching a rocket with about 600 learners from the surrounding areas. The 25-year-old from Mabopane near Pretoria will become the first black astronaut when he goes into space on the Lynx Mark II Shuttle, next year.

The outreach event will include activities such as telescope making and rocket launching. Workshops demonstrating the benefits of space science in areas such as earth observations, scientific research and development and human capital development, will also be conducted.

Among others, the open day will feature exhibitions such as the project to build the world’s largest telescope, the Square Kilometre Array and the recent launch into space of the country’s micro-satellite – ZACUBE1 built by post-graduate students at the Cape Peninsula University of Technology (CPUT).

Other exhibitors will include the Hartebeesthoek Radio Astronomy Observatory (HartRAO), the Agricultural Research Council, Denel Dynamics, the South African National Space Agency (SANSA) and the South African Weather Services (SAWS).

Officials from the provincial Department of Basic Education are also expected to attend.

Journalists are invited to the outreach

Venue: Economics Building, University of the Free State
Date: Saturday 1 March 2014
Time: 08:00

For more information, contact Veronica Mohapeloa at +27(0)82 882 3818 or +27(0)12 843 6788 or email veronica.mohapeloa@dst.gov.za OR David Mandaha at +27(0)72 126 8910 or david.mandaha@dst.gov.za

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