Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Renewal process in JBM Hertzog Residence
2014-03-19

In February 2014, the JBM Hertzog residence community initiated a process of renewal. The review and reassessment of university symbols and traditions is nothing new; it takes place on a regular basis through the institution.

This means that various conversations take place to consult students on the evaluation of their residence’s values, symbols, systems and traditions in a changing South Africa. The university is deeply committed to continuously renewing its residence cultures through focused conversations in order to be more inspiring and welcoming to all students. The involvement of students in co-creating such spaces remains paramount.

The university regrets the deliberate and misleading information in the media on the process underway in JBM. The importance of student involvement consequently calls for the distribution of accurate information in order to avoid uncertainties, misunderstandings and incorrect perceptions.

It is therefore important to state the following regarding the current renewal process in JBM Hertzog:

1. No memorabilia or photos have been removed, and no final decisions have been taken in this regard. These decisions form an integral part of the consultation process described above.

2. The name of the residence (among other symbols) is part of the consultation process. It is also important to note that all suggested name changes at the UFS are subject to the approval of the institutional Naming Committee and the University Council.

3. The perception that this process is being used to eliminate certain unique cultural identities is incorrect. However, what this process aims to achieve is a more inclusive and welcoming residence culture, and throughout this will be done in consultation with all students.

All current residents of JBM Hertzog are invited to form part of this renewal process. In conclusion, the UFS wishes to convey its appreciation to the Residence Committee members and the residents for their positive attitude and continuous support during this very important process.

Prof Jonathan Jansen
Vice-Chancellor and Rector
University of the Free State
 

Issued by: Lacea Loader (Director: Communication and Brand Management)
Telephone: +27(0)51 401 2584 or +27 (0) 83 645 2454
E-mail: news@ufs.ac.za
Fax: +27 (0) 51 444 6393

 

 

 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept