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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS blows the whistle on crime
2014-03-28


At the event were, from the left: Refiloe Seane, Director: Student Counselling and Development; Anastasia Sehlabo, SRC member for Accessibility and Student Support. Back, from the left: Melissa Barnaschone, Student Counselling and Development; and Mokgawa Kobe, Director: Protection Services.
Photo: Leonie Bolleurs

First-year students receive 1 000 whistles in project to combat crime.

Numerous safety measures were implemented by the University of the Free State in the past five years to ensure the safety of all the students and staff on all three campuses of the UFS. A large area of the UFS Campus is covered by security cameras. Red poles, equipped with panic buttons that can be activated to call for help, were also erected across the campuses.

At the beginning of 2013, as a further safety measure, whistles were handed out to female students in residences.

At an event on 26 March 2014, Refiloe Seane, Director: Student Counselling and Development, together with her team, handed over 1 000 whistles to the Student Representative Council to be distributed to first-year students. The whistles were sponsored by Prof Nicky Morgan, Vice-Rector: Operations and Mokgawa Kobe, Director: Protection Services.

“Female students are encouraged to use the whistles to call for help when they feel unsafe or are in danger. The objective is, firstly, to discourage criminals without suffering any negative consequences, and secondly, to get the attention of security or any other form of assistance,” said Melissa Barnaschone, Student Counselling and Development.

At the event, Mokgawa said: “The moment you blow this whistle, you say to the potential criminal:

  • I hate what you do
  • I will not keep quiet about it
  • I am doing something against crime.”

 

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